Transcript
[Nancy sees a sign posted on a bank window which reads: Visit our loan department]
[Nancy stands before a bank clerk]
Nancy: I’d like to borrow two dollars
Clerk: For what?
[Nancy speaking to the clerk]
Nancy: The circus is in town
Clerk: It is?
[Nancy and the clerk sit in a crowd at the circus enjoying ice cream while they watch the show. It’s loss. The comic was loss all along.]
Source
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Just kidding, it’s also loss.
I don’t get it. What’s going on in the last panel?
That’s from a web comic this comic in particular went viral as a meme. It’s called Loss and now that you’ve seen it, you’ll see it everywhere. Sometimes it’s just represented with lines or dots.
Check out the Wikipedia article on it, the meme section will show you how you might encounter it.