It doesn’t work at scale.

$1, $10, or even $100 is nothing to me or possibly you, but to someone else that is grocery money, and most of us won’t pay a dime just out of principle.

I pay around $50/mo to my favorite sites for content. I wouldn’t give Twitter a dime. If this gets the few stragglers off Twitter and onto mastodon I am all for it.

As an autistic person with ADHD I am going to leave this one alone. 😬

I can only do $3

Good luck. I switched to Firefox months ago and couldn’t be happier.

I caught it (again) and I rarely go out in public. This is the third time I have had it. Thankfully I am vaccinated + boosted so all three times have been pretty mild, though this time is definitely the most brutal.

They do, and the government has lawyers that review your case for free as well. The very first step in the complaint process is to file with the EEOC or a state agency. If they decide not to sue, you hire a lawyer on contingency and go to court.

As a US Citizen I have quite a few EU friends (I like hanging out there okay?!? and the people are mostly kinda awesome?) and the biggest and most humorous thing I have discovered is that most Europeans don’t realize how small their countries are compared to the US.

Paid sick leave, no, but your job is protected by FMLA.

People think I am full of it when I say that my household income (largish household with kids) is a quarter million a year and we are basically living like we are middle class. Money just doesn’t go as far as it used to.

As a millennial, I never would have imagined working my way up to this point only to find I can’t even buy a house. Oh sure, I could make the bare minimum down payment and get stuck with a super high mortgage payment, but if I lose my job or become disabled or unable to work, we would have no way to pay for it.

Groceries, housing, and insurance costs have more than doubled for us since 2019.

Slightly off topic. A lot of public schools already get free meals thanks to federal education dollars. The school lunches are free in my area because of this, even though the (red) state won’t act.

The state has attempted to kill off those dollars in the past.

It shipped on several different platforms. If you own the game on Steam, it was updated. Same for the consoles like the switch.

The somewhat popular “theory” is lead poisoning.

If I had the links handy I would drop them here. Not much (if any) evidence, however.

Lead poisoning makes people dumb which makes them vote “R” and do dumb stuff.

Ah, I see you live in Texas.

The problem is that if you get caught you can be charged a federal crime instead of with a state crime.

Federal crimes include mandatory minimum sentences/jail time in addition to fines.

Believe me, I have thought about making the trip elsewhere since my state will be the last to ever legalize. The closest legal place is 2.5 hours from my house.

Me getting caught would screw up multiple lives including my own, however. Instead, I have to settle for the poor man’s stuff (delta8, delta9, etc) and only get the real stuff when I travel. The poor man’s stuff helps a medical condition I have, but is nothing like the real thing.

Most folks I follow went to Mastodon. I even met some new folks, including some that are local!

Some are still on twitter even though a small number of us begged/pleaded with them.

One went to blue sky.

It gets below zero in the north east in the winter. Heat pumps stop working at 20-30F and the system has to switch to classic/emergency heat. They are great for fall/spring (or summer as an AC), but useless for winter.

The bigger issue is that it is extremely expensive to install ductwork, wiring for 1 or more thermostats, and a shiny new heating/cooling system in many existing homes that use classic radiator heat. Depending on where the oil tank is located, it may require removal as well (example: if it is underground, depending on state/municipal laws).

Nice. That response letter wasn’t exactly legalese, but was outstanding.

I think the issue is that some of us know this, but most are getting blasted by the media non-stop, and some of the messaging is even outright denying climate change exists. After a while people get tired of hearing about it.

I don’t have an answer for how to solve that one except to say that regardless of who is saying what or how loud, governments around the world aren’t doing enough. It is amazing to me because at the end of the day, money can slow and eventually stop/reverse climate change. We have the technology, we just need to invest in the required infrastructure and technology to make it happen.

Climate change isn’t political. It will kill all of us if left unchecked.

I think I do. So much in terms of doom and gloom is being shouted in terms of climate change that many are becoming numb to it, which is dangerous.

He is wrong about 1.5C not being an issue, however. 1.5C != “every place will raise only by 1.5C”. It means localized temperatures in many areas will be much, MUCH higher, as parts of the US are beginning to find out.

Responsible messaging is important, but the looming catastrophe cannot be understated. You or someone you know will likely die from global warming, if it hasn’t happened already.

Scientists at Harvard University claim to have come excitingly close to finding the proverbial Fountain of Youth. According to a recent publication in the scientific journal Aging, the team has identified six chemical concoctions that have the ability to reverse the aging process in both human and mice skin cells.

Dr. David Sinclair, a molecular biologist at Harvard Medical School and co-author of the study, has hailed this as a “breakthrough” and sees it as a step towards “affordable whole-body rejuvenation.”

Dr. Sinclair has even suggested that human trials could commence within the next year. This prediction has caught the attention of prominent figures, such as tech mogul Elon Musk. He responded to the news with curiosity asking, “Ok, so what exactly is it?”

How to create a Fountain of Youth pill

The researchers utilized high-throughput cell-based assays to distinguish young cells from their older, senescent counterparts. These senescent cells are cells that have stopped multiplying, a characteristic hallmark of aging.

Through high-throughput screening, the team was able to rapidly test thousands to millions of samples for biological activity at the model organism, cellular, pathway, or molecular level.

The specific markers used for aging included transcription-based aging clocks and real-time nucleocytoplasmic protein compartmentalisation (NCC) assay. NCC is a vital function in cells, including stem cells, bone cells, and muscle cells.

Six chemical cocktails for anti-aging

This comprehensive approach culminated in the identification of six chemical mixtures that, according to the press release, “restored NCC and genome-wide transcript profiles to youthful states and reversed transcriptomic age [biological age] in less than a week.”

Upon testing these cocktails on mice and human cells, the results suggested a de-aging effect for all six combinations.

“The effect of this four-day treatment is comparable to the total change seen after a year of a regenerative treatment described in a landmark study from 2019, which also focused on restoring epigenetic information,” said the researchers. Researchers evaluated age changes using rodent and human transcriptomic clocks, which predict biological age using gene expression data.

“This new discovery offers the potential to reverse aging with a single pill, with applications ranging from improving eyesight to effectively treating age-related diseases,” said Dr. Sinclair.

Some experts are skeptical

However, other biologists have met this enthusiastic claim with skepticism. Matt Kaeberlein, a biogerontologist, offered cautious praise. He says that the innovative screening method could one day lead to significant discoveries. However, he also noted that the study is preliminary.

Kaeberlein suggested that the team should have validated at least one of the concoctions in an animal model. He believes they also should have shown improvements in age-related health metrics or lifespan before making these claims about effects on biological aging.

Dr. Charles Brenner, a metabolism researcher, raised concerns about three compounds in the study. The first is CHIR99021, which blocks glycogen formation activated during sleep to store energy. Next is tranylcypromine, an antidepressant. Finally,valproic acid, used to treat bipolar disorder but can potentially harm the liver.

The study did not mention these potential risks. Brenner warned, “These are generally not safe alone or in a combination.”

Moreover, Brenner criticized the study for not using single-cell sequencing to evaluate cell identity. He pointed out that researchers initially reported these cocktails in 2013, suggesting that the compounds are not new discoveries. “Getting these readouts on cells is not a groundbreaking study on reversal of aging,” said Brenner.

Amidst this range of responses, it’s clear that we need to conduct further research and careful examination before we can proclaim the arrival of a true Fountain of Youth pill.