ELI5 about the Chinese real estate market in general? This is how they got to where they are today:

• Investing in China sucks. The stock market is extremely volatile and there seem to be a lot of shady activities, banks get bank runs so you couldn’t even put too much money in banks, etc
• In contrast, real estate is heavily subsidized by China’s state capitalistic approach, so it became a really “stable” investment… because government subsidized it
• Because of this, everyone buys or want to buy real estate in China. In fact, people are willing to buy places that would almost never be lived in, because of possibility of appreciation… so we’re approaching NFT-level bullshit here
• Additional point: because of the above point, Chinese investors would buy real estate even when abroad & the RE market is not nearly as favorable. Obviously this causes some frictions… like a good chunk of Canadian citizen blaming Chinese ppl on raising home prices
• Chinese economy is now facing hardship, so the real estate bubble is finally showing signs of leakage in the past few years

I am not an economist and cannot offer insight as to whether this would turn into an 2008 moment… Nevertheless, I am aware that Soho is an extremely well-known developer, and that the Chinese economy is to a large extent built on top of real estate. And despite how much I dislike China, it is one of the world’s largest economies, and large economies don’t just go belly-up without inflicting heavy damage on the whole world… So this is not good news by any means.

Hey OP, I am similar to you in most aspects but I’m a lot younger, so please take it with a grain of salt…

I also live in Texas, and honestly I thought a lot of less privileged folks or ppl with family ties would love to be in your situation and just leave? It’s not just about politics. Even if tomorrow Texas becomes a liberal stronghold, it will still take possibly at least a decade to fix ERCOT, the climate issue, and flooding issues (if you live in Houston)… This clusterfrick alone was enough to prompt me to never live in Texas again once I’m done with grad school

Besides, my understanding is that there are a few left-leaning metro areas which have suburbs (or live in the city!) that don’t cost that much more to live in compared to mid-/upper-mid-class TX suburbs, so there’s probably no financial disincentive to move either

Oh boy it’s my time to shine!

I’m working in aging right now. Heard of Dr. David Sinclair since he was the corresponding author on a paper I was curious about… So this is what his lab is doing.

Two important disclaimers:

• Success in cellular research rarely translates to something viable in the clinic. A lot of chemicals don’t behave the same way in cells as in actual animals or humans. Heck, a good number of phase 2 drugs even fail, and these haven’t even made it into phase 1… so I wouldn’t be too optimistic about them.
• The journal Aging is not the most prestigious journal especially for someone working at Harvard Medical School (HMS) to be honest. I’d be more excited if this was published in Nature Aging or Nature Communications or something. If this ever gets published in New England Journal of Medicine (a very prestigious journal only for clinical studies) then we have some news.

The link between cell senescence and aging is something actively being studied tho.

And, if anyone is curious about this topic: I’m also very actively following Dr. Vadim Gladyshev who is also from HMS and is working in aging, I believe he is doing some wet lab-biology on a similar area as well. Feels like his research is sometimes a bit ahead of his time but I think his work has great potential.

Tried it myself with hardened Firefox, can confirm that’s the case. It’s even worse, my first search is “getting run over”…

Probably says more about the type of ppl frequenting YouTube than YT doing some shady stuff. Which honestly sounds more dystopian to me

P.S. Just realized youtube.com blocks Tor Browser, not cool Ytb.

Great article… Pharmaceuticals is interesting since the needs of corporations functioning under capitalism and their customers disconnect a lot

• Making effective drugs is mad expensive (billions of USD), so companies are strongly incentivized to squeeze as much profit as possible everywhere on top of the already bad enough corporate greed levels
• Thanks to patents, new drugs are almost always monopolies, so the pharma who makes the drug can charge (almost) as much as they want and make a lot
• Whereas making drugs without patents is not profitable as the article suggested… so these are done mostly by factories based in India and other not fully developed countries
• Funnily enough most ppl need cheaper generic drugs, not the ones most pharma companies are innovating and will make mad profits from
• And for the people mentioned above, pharmaceuticals are basically a need not a luxury, but somehow it’s dependent on the ebbs and flows of free market capitalism

My unhinged opinion is… Most of the pharmaceuticals research are done by (mostly) publicly-funded research labs anyways… so might as well just let the government do something about this? I wouldn’t be surprised if some folks in academia wouldn’t mind moonlighting as CEO at a nonprofit drug manufacturer or sth

Calckey is a Misskey (https://misskey.io/) fork, hence the name. Misskey is an extremely popular fediverse microblogging service from Japan with a lot of functionalities that Mastodon doesn’t have (quote toot, emoji react, …), in fact if you follow any Japanese accounts on Mastodon there is a good chance they are using Misskey instead

Basically Calckey diverged enough from Misskey (and I suspect Kainoa didn’t like the name) that they agreed to rebrand. Kind of a big deal tbh

Surprised no one else mentioned this… the answer is negative many months (or years?), most are Mastodon instances and probably not many people are familiar with most of those instances tho.

There was a fairly serious controversy months back when mastodon.cloud was purchased (if I remember correctly) by the same company that owns pawoo.net and another large Japanese Mastodon instance, the company is for-profit. Several right-wing shithole instances obviously have ads and are for-profit. Also there are a few instances owned/operated by for-profit companies, Medium immediately comes to the top of my mind.

Problem is a fairly significant portion of Mastodon admins I know were so staunchly against anything touching for-profit companies within a 12-ft stick that they immediately defederated from all of the said for-profit company affiliated instances…

To answer the second question… I don’t know. Again, the larger Mastodon instances (over 10,000 users each) I’m aware of seem to do just fine on user donations now, but the concept of profit comes every now and then. Paid moderators/admins was also something to keep in mind for this topic.