Kavanaugh said in dissent that the court’s decision will have a “devastating” impact on thousands of victims of the opioid epidemic.
"As a result, opioid victims are now deprived of the substantial monetary recovery that they long fought for and finally secured after years of litigation,” he wrote in the dissent, which was joined by Chief Justice John Roberts and liberal Justices Sonia Sotomayor and Elena Kagan.
It’s important to note that in historical examples of these settlements, the money was us d as a slush fund.
When tobacco did their settlement, it was used for stuff like schools and toads, then taxes were cut instead. Resulting in no increase in funding then when the settlement money ran out, they were broke. In some cases the settlement money was even used to pay for tobacco infrastructure (auction houses and such).
Can’t remember if it was Oliver or Stewart, but one of them did a show/segment on it recently.
And that’s not even getting into the settlement didn’t touch any of the Sacker money directly.
And the company 100% knew that extended release wouldn’t work the same on everyone, some people would be pretty much guaranteed to become addicts if they followed their prescriptions. They’d just naturally metabolize it too fast.
But they made more money. So they pushed XR to doctors and patients while hiding the fact that it was dangerous.
They need to be in jail, which won’t happen. But we can at least fuck their personal blood money up.
XR/Extended Release
I’m very surprised the pharmaceutical market hasn’t produced the opioid analogue to Vyvanse requiring enzymatic conversion as opposed to mechanical release -> long lasting natural extended release mechanism. Its a great idea that hasn’t seemed to expand to many other therapeutic agents
I don’t know vyvanse xr method of action off the top of my head…
But for opioids the difference in in enzymatic breakdown is already problematic.
Even for non XR, some people just burn thru it at different rates.
Personally I don’t have enough of a couple of the L enzymes and that means most opioids barely do anything to me. Some people have too much and will burn thru a Vicodin in half as much time, leaving them unmedicated for half the time.
There’s just too much human variation for a one sized fits all approach.
The point I’m making is, while I’m aware of people being fast or slow metabolizers, that should only factor in when it comes to active ingredient that is fully mechanically released and available for metabolism.
It cannot metabolize that which has not either been a) mechanically released or b) that which is pharmacodynamically inertt since it requires cleaving off the other binding substance (like l-lysine in Vyvanse) before the underlying active drug can be mechanically available to metabolize if that makes sense.
Vyvanse cannot be injected or administered in basically any other ROA than oral like normal dex because it (lis-dexamferamine—not dextroamphetamine) is inert until it has undergone the uncleaving of lysine from the active drug. Doesn’t matter how fast one metabolizes dextro, nobody metabolizes lis as a straight stimulant, it is inert until made not so thru the blood or whatever.
Also, doesn’t that mostly apply to codeine and morphine, wasn’t aware of that extending to oxy and hydro?
Also, doesn’t that mostly apply to codeine and morphine, wasn’t aware of that extending to oxy and hydro?
Morphine (not sure about codeine) are/is one of the few options that are direct acting.
Oxy, Vicodin, and all the rest first get broken down I to an active metobalite. Even if they’re not XR. XR just compounds the issue
I feel bad for the folks that need and deserve that money from the settlement, but it was unconscionable to allow the Sackler fucks to walk away immune with their billions. Fuck that family. I hope they get sued all the way to the poor house and found criminally liable.
