Seinfeld- Jerry and Elaine are exes and breify get back together at the end of season one
Friends- lots of romantic entaglements but mainly Chandler/Monica, Ross/Rachel, and Joey/Rachel
How I Met Your Mother - two of the main characters are a steady couple, the other three are a love triangle
Big Bang Theory- by the end, it’s three couples and one single guy
Any shows like these where the main characters never date each other or hook up with each other?
I want to say Resident Alien. The core 3 adult friends don’t have any romantic relations as far as I remember. Although there is one love triangle involving one of the main and side characters I guess. But the majority of the show is about real beautiful mixed-gender friendships IMO.
Harry and D’Arcy dated for a few episodes (maybe only one or two, I don’t recall clearly). There was a bit of teasing that Asta and Harry would be a thing at some point but thankfully that never materialized.
There were definitely romantic relationships with side characters - Sheriff Mike had a couple, obviously the mayor and his wife, Harry and the bird lady, Liz had a boyfriend (though he rarely appeared or was even mentioned), plus D’Arcy tried a few times to find love and Judy… had several flings?